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pentobarbital will minimize the level or impact of pioglitazone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Not known.Monitor Intently (1)pentobarbital will minimize the level or effect of fentanyl by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Coadministration of